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[慶賀]恭喜張清貿醫師升任北榮傳醫科主治醫師-20170201

作者 主題: [mRNA] MYC  (閱讀 13 次)

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[mRNA] MYC
« 於: 四月 18, 2017, 09:35:22 pm »
MYC proto-oncogene, bHLH transcription factor
https://ghr.nlm.nih.gov/gene/MYC
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
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